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작성자 Bobbye
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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described as a focus on the practical aspects of study design which include recruitment and consent, adherence and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be valid, and it also helps to reduce the chance of bias in the results. A high degree of heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually requested by practitioners and policy makers to aid in their decision-making. They can be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or 프라그마틱 슬롯 환수율 physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study, including recruitment, design, implementation of the intervention, and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.

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